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. 2011 Jul 15;39(20):8752–8764. doi: 10.1093/nar/gkr537

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Representative structures of the cis-B[a]P-dG-modified full and deletion duplexes. Hydrogen atoms and phosphate oxygen atoms are deleted for clarity. The lesion strand backbone is in light gray and the complementary strand is in dark gray. Phosphate atoms are purple. The adduct is red, the modified guanine and its partner base are cyan, and the neighboring bases are blue. (A) Best representative structure of the cis-B[a]P-dG-modified full duplex viewed from the minor groove and along the helix axis. The best representative structure viewed along the helix axis (Top view) is shown on the right to emphasize stacking interactions with neighboring bases. (B) Best representative structure of the cis-B[a]P-dG-modified deletion duplex viewed from the minor groove, along the helix axis and from the major groove. The best representative structure viewed along the helix axis (Top view) is shown in the middle to emphasize stacking interactions with neighboring bases. The best representative structure viewed from the major groove side is shown on the right to emphasize the wedge-like shape induced by the deletion.