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. 2011 Jul 23;39(20):8677–8688. doi: 10.1093/nar/gkr593

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Subnetworks obtained by collecting the top 1000 connections with the highest MI within the network. Subnetwork (a) contains genes that codify for the ‘ribosomal protein complex’, (‘Translation’, P < 1.0⁻¹¹³). Subnetwork (b) is enriched for genes involved in the ‘spindle checkpoint’ (‘Nuclear division’ P < 3.1⁻⁷), for clarity only a subset of interactions are shown. Subnetwork (c) is enriched for ‘metallothionein’ genes, a family of low molecular weight, heavy metal binding proteins. Subnetwork (d) contains major histocompatibility complex proteins (Antigen processing and presentation, P < 7.5⁻¹⁶). Pairs of genes are connected if their MI (probabilistic measure of relatedness) confirms a significant co-regulation.