Table 2.

Summary of inhibition studies of various RNAs with ligands 2 and 3

RNAa	tRNA (nM)	Kd (nM)	[MBNL1] (nM)	2		3
				IC50 (µM)	Ki (µM)	IC50 (µM)	Ki (µM)
(CCUG)6	–	15 ± 2	350	59 ± 5	2.5 ± 0.2	52 ± 8	2.2 ± 0.3
	100	30 ± 4	350	40 ± 11	3.4 ± 0.9	35 ± 3	3.0 ± 0.3
(CUG)12	–	150 ± 20	1000	37 ± 11	5.5 ± 1.4	118 ± 40	18 ± 5
cTNTb(I)	–	1.0 ± 0.2	15	101 ± 26	6.7 ± 1.6	>250	>17

^aRNA concentrations were 0.1 nM. ^b18-nt fragment of the cTNT pre-mRNA (RNA I in Figure 6).