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. 2011 Apr 27;26(11):3465–3473. doi: 10.1093/ndt/gfr110

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© The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — Tubulointerstitial damage in Tg and WT mice with anti-GBM GN at Day 7. (a) The tubulointerstitial injury score was attenuated significantly in Tg mice (versus WT; *P < 0.001) (n = 5 in each group). (b) The number of macrophages was also significantly lower in Tg mice (versus WT; *P < 0.001). (c) Interstitial expression of markers of oxidative stress (HNE) and fibrosis (α-SMA) were attenuated in Tg mice. (d) Immunohistochemical analysis showed reduced tubular expression of the marker of proximal tubular damage, Kim-1, in Tg mice. Western blotting further confirmed this significant reduction (versus WT; **P < 0.01). Arrows indicate the position of Kim-1-specific bands at ∼40 and 70–80 kDa. Data are expressed as mean ± SD.