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. 2011 Feb 1;21(4):609–626. doi: 10.1038/cr.2011.17

Figure 6.

Figure 6

Slit-Robo signaling degrades E-cad. (A-F) HCT116/V, HCT116/Robo1, HCT116/Robo1/Slit2, SW620/V and SW620/shRobo1 cells were treated with CHX, in the absence or presence of mIgG, R5, PBS and hSlit2, for a period of time as indicated. Cell lysates were immunoblotted with the Abs to E-cad (left upper panels) and α-tubulin (left lower panels) and a ratio of E-cad over α-tubulin (right panels) was calculated. Results are representative of at least three independent experiments (left panels) or the mean±S.D. of three independent experiments (right panels).