Table 2.
Patient cohorts and DLTs
| Dose level | Schedule | 17-AAG dose (mg/m2) | Cycle duration (d) | Patients | DLTs | Description of DLTs |
|---|---|---|---|---|---|---|
| 1 | Daily × 5 | 5 | 21 | 1 | 0 | |
| 2 | Daily × 5 | 10 | 21 | 1 | 0 | |
| 3 | Daily × 5 | 20 | 21 | 2 | 0 | |
| 4 | Daily × 5 | 40 | 21 | 3 | 0 | |
| 5 | Daily × 5 | 80 | 21 | 7 | 2 | Thrombocytopenia (1 pt), diarrhea/hepatitis (1 pt) |
| 6 | Daily × 5 | 56 | 21 | 3 | 0 | |
| 7 | Daily × 3 | 80 | 14 | 3 | 0 | |
| 8 | Daily × 3 | 112 | 14 | 8 | 1 | Emesis (1 pt) |
| 9 | Daily × 3 | 157 | 14 | 4 | 2 | Nausea (1 pt), dyspnea (1 pt) |
| 10 | Days 1, 4, 8, and 11 | 112 | 21 | 3 | 0 | |
| 11 | Days 1, 4, 8, and 11 | 157 | 21 | 4 | 0 | |
| 12 | Days 1, 4, 8, and 11 | 220 | 21 | 6 | 1 | Hepatitis (1 pt) |
| 13 | Days 1, 4, 8, and 11 | 307 | 21 | 3 | 2 | Seizure (1 pt), abdominal pain/nausea/fever (1 pt) |
| 14 | Days 1 and 4 | 150 | 21 | 3 | 0 | |
| 15 | Days 1 and 4 | 210 | 21 | 3 | 0 |