Table 3.

Adverse events (all cycles)

	Daily × 5				Daily × 3
	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4
No. patients	17				15
No. courses	50				55
Adverse events
Nausea	9 (53%)	1 (6%)	—	—	6 (40%)	1 (7%)	1 (7%)	—
Emesis	5 (29%)	1 (6%)	—	—	2 (13%)	1 (7%)	1 (7%)	—
Diarrhea	3 (18%)	1 (6%)	1 (6%)	—	5 (33%)	3 (20%)	—	—
AST	6 (35%)	2 (12%)	1 (6%)	1 (6%)	6 (40%)	4 (27%)	—	—
ALT	5 (29%)	1 (6%)	1 (6%)	1 (6%)	6 (40%)	2 (13%)	1 (7%)*	—
Platelets	3 (18%)	—	1 (6%)	—	4 (27%)	1 (7%)	—	—

	Days 1, 4, 8, and 11				Days 1 and 4 weekly
	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4
No. patients	16				6
No. courses	56				33
Adverse events
Nausea	6 (38%)	4 (25%)	—	—	1 (17%)	2 (33%)	—	—
Emesis	4 (25%)	2 (13%)	—	—	—	1 (17%)	—	—
Diarrhea	5 (31%)	3 (19%)	1 (6%)	—	3 (50%)	1 (17%)	—	—
AST	4 (25%)	4 (25%)	—	—	1 (17%)	1 (17%)	2 (33%)	1 (17%)
ALT	4 (25%)	1 (6%)	—	—	—	1 (17%)	4 (67%)	—
Platelets	2 (13%)	—	—	—	—	—	1 (17%)	—

^*Abnormal lab value in this patient likely attributable to antibiotic therapy.