Table 3.
Rectal temperature and heart rate on the day of the 30-min coronary occlusion
| Occlusion, min |
Reperfusion, min |
||||||
|---|---|---|---|---|---|---|---|
| Group | Preocclusion | 5 | 15 | 30 | 1 | 10 | 15 |
| Temperature, °C | |||||||
| I (B6129, AMI) | 36.8 ± 0.1 | 37.1 ± 0.1 | 37.1 ± 0.1 | 37.2 ± 0.1 | 37.0 ± 0.1 | 36.8 ± 0.1 | 37.0 ± 0.1 |
| II (iNOS–/–, AMI) | 36.9 ± 0.1 | 37.2 ± 0.1 | 37.2 ± 0.1 | 37.0 ± 0.1 | 37.0 ± 0.1 | 37.0 ± 0.1 | 37.0 ± 0.1 |
| III (B6129, DETA/NO) | 37.1 ± 0.1 | 37.1 ± 0.0 | 37.2 ± 0.0 | 37.1 ± 0.0 | 37.1 ± 0.0 | 37.1 ± 0.1 | 37.1 ± 0.1 |
| IV (iNOS–/–, DETA/NO) | 37.0 ± 0.1 | 37.1 ± 0.1 | 37.2 ± 0.1 | 37.2 ± 0.1 | 37.2 ± 0.1 | 37.2 ± 0.1 | 37.1 ± 0.1 |
| V (B6129, NTG) | 37.0 ± 0.1 | 37.1 ± 0.1 | 37.1 ± 0.1 | 37.0 ± 0.0 | 37.0 ± 0.1 | 37.1 ± 0.1 | 37.0 ± 0.0 |
| VI (iNOS–/–, NTG) | 37.0 ± 0.1 | 37.2 ± 0.1 | 37.2 ± 0.0 | 37.2 ± 0.1 | 37.1 ± 0.1 | 37.0 ± 0.1 | 37.1 ± 0.1 |
| VII (B6129, SNAP) | 37.1 ± 0.1 | 37.2 ± 0.1 | 37.2 ± 0.1 | 37.0 ± 0.1 | 37.1 ± 0.1 | 37.0 ± 0.0 | 37.1 ± 0.0 |
| VIII (iNOS–/–, SNAP) | 36.9 ± 0.1 | 37.2 ± 0.1 | 37.1 ± 0.1 | 37.2 ± 0.1 | 37.1 ± 0.1 | 36.9 ± 0.1 | 37.0 ± 0.1 |
| IX (B6129, TAN-670) | 36.9 ± 0.1 | 37.1 ± 0.1 | 37.1 ± 0.1 | 37.1 ± 0.1 | 37.1 ± 0.0 | 37.0 ± 0.1 | 36.9 ± 0.1 |
| X (iNOS–/–, TAN-670) | 37.0 ± 0.1 | 37.0 ± 0.1 | 37.2 ± 0.0 | 37.2 ± 0.1 | 37.1 ± 0.0 | 37.0 ± 0.1 | 37.1 ± 0.0 |
| XI (1400W, TAN-670) | 37.1 ± 0.1 | 37.1 ± 0.1 | 37.1 ± 0.1 | 37.0 ± 0.0 | 37.0 ± 0.0 | 36.9 ± 0.1 | 37.0 ± 0.1 |
| XII (B6129, CCPA) | 37.0 ± 0.1 | 37.1 ± 0.1 | 37.2 ± 0.1 | 37.1 ± 0.0 | 37.0 ± 0.1 | 37.1 ± 0.0 | 37.1 ± 0.1 |
| XIII (iNOS–/–, CCPA) | 37.0 ± 0.1 | 37.1 ± 0.0 | 37.0 ± 0.1 | 37.1 ± 0.0 | 37.0 ± 0.0 | 37.0 ± 0.0 | 37.1 ± 0.1 |
| XIV (1400W, CCPA) | 36.8 ± 0.1 | 37.2 ± 0.1 | 37.0 ± 0.1 | 37.1 ± 0.0 | 36.8 ± 0.1 | 37.0 ± 0.1 | 37.0 ± 0.1 |
| XV (B6129, LPC) | 36.9 ± 0.1 | 37.3 ± 0.1 | 37.1 ± 0.1 | 37.0 ± 0.1 | 37.3 ± 0.1 | 36.8 ± 0.1 | 37.0 ± 0.1 |
| Heart rate, beats/min | |||||||
| I (B6129, AMI) | 544 ± 12 | 570 ± 14 | 585 ± 22 | 588 ± 22 | 584 ± 23 | 585 ± 20 | 600 ± 24 |
| II (iNOS–/–, AMI) | 523 ± 13 | 522 ± 14 | 515 ± 18 | 517 ± 15 | 502 ± 19 | 548 ± 21 | 567 ± 15 |
| III (B6129, DETA/NO) | 556 ± 12 | 573 ± 10 | 563 ± 10 | 569 ± 10 | 578 ± 9 | 597 ± 10 | 614 ± 13 |
| IV (iNOS–/–, DETA/NO) | 548 ± 17 | 567 ± 17 | 556 ± 16 | 547 ± 15 | 552 ± 12 | 570 ± 9 | 571 ± 13 |
| V (B6129, NTG) | 576 ± 17 | 592 ± 14 | 615 ± 16 | 612 ± 11 | 610 ± 14 | 628 ± 18 | 631 ± 18 |
| VI (iNOS–/–, NTG) | 540 ± 11 | 563 ± 18 | 575 ± 21 | 596 ± 20 | 593 ± 22 | 603 ± 20 | 603 ± 23 |
| VII (B6129, SNAP) | 556 ± 16 | 566 ± 19 | 570 ± 19 | 566 ± 14 | 562 ± 16 | 573 ± 17 | 576 ± 19 |
| VIII (iNOS–/–, SNAP) | 547 ± 8 | 588 ± 8 | 574 ± 17 | 584 ± 15 | 577 ± 15 | 563 ± 16 | 571 ± 14 |
| IX (B6129, TAN-670) | 485 ± 10 | 538 ± 12 | 547 ± 7 | 556 ± 11 | 543 ± 11 | 527 ± 13 | 527 ± 13 |
| X (iNOS–/–, TAN-670) | 517 ± 9 | 579 ± 13 | 594 ± 18 | 602 ± 21 | 601 ± 21 | 598 ± 19 | 597 ± 21 |
| XI (1400W, TAN-670) | 511 ± 15 | 546 ± 15 | 562 ± 11 | 573 ± 11 | 559 ± 15 | 556 ± 15 | 547 ± 17 |
| XII (B6129, CCPA) | 547 ± 14 | 560 ± 13 | 571 ± 20 | 580 ± 17 | 574 ± 20 | 573 ± 14 | 565 ± 18 |
| XIII (iNOS–/–, CCPA) | 513 ± 21 | 579 ± 13 | 596 ± 14 | 606 ± 15 | 599 ± 16 | 593 ± 15 | 578 ± 17 |
| XIV (1400W, CCPA) | 532 ± 17 | 536 ± 17 | 587 ± 23 | 606 ± 28 | 592 ± 29 | 595 ± 29 | 592 ± 28 |
| XV (B6129, LPC) | 551 ± 14 | 566 ± 16 | 565 ± 17 | 572 ± 16 | 572 ± 17 | 581 ± 21 | 576 ± 18 |
Values are means ± SE. Measurements of rectal temperature and heart rate were taken before 30-min coronary occlusion (preocclusion), at 5, 15 and 30 min into 30-min occlusion and at 1, 10, and 15 min after reperfusion. Rectal temperature was continuously monitored and carefully controlled throughout experiment. AMI, acute myocardial infarction; iNOS–/–, inducible nitric oxide synthase knockout mice; LPC, late preconditioning.