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. 2011 Oct 28;6(10):e26367. doi: 10.1371/journal.pone.0026367

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Koh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Peptides are grouped according to their mechanism of actions. All competitive inhibitors (fast or slow) have higher affinities to thrombin compared to hirulog-1/bivalirudin. The most potent variant DV24K10RY^sulf is about 70-fold stronger. Even their cleavage products (non-competitive inhibitors) are potent inhibitor, with one of them, MH18Y^sulf, binds to thrombin approximately 2-fold tighter than hirulog-1/bivalirudin.