Table 1. Clinical characteristics of study subjects.
| Baseline | 24 weeks | 48 weeks | |
| Waist circumference (cm) | 88.2±7.3 | 87.1±9.0 | 87.4±8.3 |
| BMI (kg/m2) | 25.0±2.9 | 24.8±3.2 | 24.8±3.0 |
| SBP (mmHg) | 128.1±17.3 | 127.7±16.7 | 125.7±17.1 |
| DBP (mmHg) | 83.4±10.0 | 80.7±9.3* | 79.4±9.1* |
| TC (mmol/l) | 5.4±1.2 | 5.5±1.2 | 5.5±1.2 |
| TG (mmol/l)† | 1.9 (1.2–2.8) | 1.8 (1.3–2.5) | 1.9 (1.1–2.8) |
| HDL-c (mmol/l) | 1.2±0.2 | 1.3±0.3 | 1.3±0.3* |
| LDL-c (mmol/l) | 3.4±1.0 | 3.2±0.9 | 3.2±0.9 |
| Fasting insulin (mU/l) | 14.2±7.1 | 15.8±7.5 | 16.2±9.8 |
| FPG (mmol/l) | 8.9±1.8 | 6.3±0.9* | 6.5±1.2* |
| 2hPG (mmol/l) | 13.5±3.2 | 8.3±2.5* | 8.7±2.1* |
| HbA1c (%) | 8.2±1.5 | 6.3±0.6* | 6.3±0.7* |
| HOMA-IR | 6.5±3.7 | 4.1±2.4* | 4.5±3.4* |
| HOMA-B%† | 72.2 (44.3–123.3) | 94.2 (68.3–152.8) | 91.6 (60.7–134.3) |
| AIR (mU/l)† | 22.2 (12.5–36.3) | 19.0 (11.1–34.6) | 22.7 (11.3–39.0) |
Data are mean ± SD or median (interquartile range). AIR: acute insulin response; BMI: body mass index; DBP, diastolic blood pressure; FPG: fasting plasma glucose; 2hPG: 2-h postchallenge plasma glucose; HbA1c: glycated hemoglobin A1c; HDL-c: high density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment index of insulin resistance; HOMA-B%: homeostasis model assessment index of beta cell function; LDL-c: low density lipoprotein cholesterol; SBP, systolic blood pressure; TC: total cholesterol; TG: triglyceride.
†
Log transformed before analysis.
*P<0.01 vs. baseline.