Table 1.
Results (POAF) | |||||||
Study | N | Study design | Control | Inclusion criteria | Exclusion criteria | PUFA | Control |
Calo | 160 | Open-label, prospective, randomized, controlled trial with parallel groups; not blinded | No PUFA | Age >18, NSR, stable hemodynamic conditions before surgery | Concomitant valvular surgery, a prior history of any SVT, the current use of an AAD other than BB, CCB, or digitalis | 15.2% | 33.3% |
Heidt | 102 | Prospective, randomized double-blinded trial | IV saturated free fatty acids | Age >18, NSR, stable hemodynamic conditions before surgery, no angina at rest | Concomitant valvular surgery, a prior history of any SVT, the current use of an AAD other than BB or CCB | 17.3% | 30.6% |
Heidarsdottir | 168 | Prospective, randomized, double-blinded, placebo-controlled trial | Placebo | All of the consecutive patients scheduled for elective or open heart surgery | Age <40, prior history of any SVT, the current use of amiodarone or sotalol, an emergent operation | 54.2% | 54.1% |
Saravanan | 103 | Prospective, randomized, double-blinded, placebo-controlled trial | Placebo | Age >18, scheduled to undergo elective isolated CABG | A prior history of any atrial arrhythmia, the current use of a class-1 or class-3 AAD, fish oil use within 3 mos prior to surgery | 56% | 43% |
AAD, antiarrhythmic drugs; BB, beta-blockers; CABG, coronary artery bypass grafting; CCB, calcium channel blockers; IV, intravenous; NSR, normal sinus rhythm; POAF, postoperative atrial fibrillation; PUFA, polyunsaturated fatty acid; SVT, supraventricular tachycardia.