Table 4.
Association between drug dose and duration of aspirin and non-aspirin NSAID and adenomatous polyp risk, the Tennessee Colorectal Polyp Study
| Adenomatous Polyp |
|||
|---|---|---|---|
| NSAID use | Controls | Cases | OR* (95% CI) |
| Never | 1654 | 748 | 1.00 |
| Aspirin only use | |||
| ≤ 7 doses a week | |||
| < 5 years of use | 400 | 174 | 0.73 (0.59, 0.91) |
| ≥ 5 years of use | 543 | 270 | 0.77 (0.64, 0.94) |
| > 7 doses a week | |||
| < 5 years of use | 32 | 15 | 0.69 (0.36, 1.31) |
| ≥ 5 years of use | 78 | 51 | 0.92 (0.61, 1.36) |
| P-interaction | 0.37 | ||
| Single agent non-aspirin NSAID | |||
| ≤ 7 doses a week | |||
| < 5 years of use | 84 | 27 | 0.62 (0.39, 0.99) |
| ≥ 5 years of use | 121 | 45 | 0.85 (0.59, 1.24) |
| > 7 doses a week | |||
| < 5 years of use | 92 | 31 | 0.60 (0.38, 0.93) |
| ≥ 5 years of use | 123 | 43 | 0.58 (0.40, 0.86) |
| P-interaction | 0.43 | ||
| Any combination of NSAID | |||
| ≤ 7 doses a week | |||
| < 5 years of use | 30 | 15 | 0.68 (0.35, 1.33) |
| ≥ 5 years of use | 93 | 50 | 0.89 (0.61, 1.30) |
| > 7 doses a week | |||
| < 5 years of use | 27 | 7 | 0.42 (0.18, 0.99) |
| ≥ 5 years of use | 154 | 53 | 0.45 (0.32, 0.64) |
| P-interaction | 0.83 | ||
*
Adjusted for age, gender, race, family history, education level, body mass index, energy intake, smoking status, alcohol use, physical activity, use of hormone replacement therapy, indication for colonoscopy, study site, and year of study enrollment.