Fig. 1.
Teratoma growth after injection of MPI-II ESCs is accelerated in SCID/beige compared to SCID and syngeneic 129Sv mice. The 1 × 106 MPI-II ESCs were injected subcutaneously at day 0 into syngeneic 129Sv mice (n = 26), T and B cell-deficient SCID (n = 14) and T, B, and NK cell-deficient SCID/beige mice (n = 15). The tumor size was recorded every second day using linear calipers. A summary of the growth (mean ± standard error of the mean) until day 30 is shown, newly evaluating previously published data [61]. The comparison of tumor size in SCID and SCID/beige or 129Sv mice, respectively, indicates a significant difference at days 18, 20, 22, 28, and 30 (P < 0.05, unpaired t test)