. Author manuscript; available in PMC: 2012 Oct 28.

Published in final edited form as: J Nat Prod. 2011 Oct 3;74(10):2039–2044. doi: 10.1021/np200532d

Table 2.

Comparative Analysis of the NCI 60 Data for Compounds 1 and 2.

Cell Panel	Cell Line	TGI (μM)			LC₅₀ (μM)
Cell Panel	Cell Line	FK228 (1)	Spir. C (2)	TGI ratio^a	FK228 (1)	Spir. C (2)	LC₅₀ ratio^b
Renal	UO-31	1.55	0.32	4.9
Renal	ACHN	0.73	0.18	4.0	5.37
Breast	MDA-MB-468	0.090	0.023	3.9	4.14
Renal	RXF 393	0.062	0.016	3.8	0.30	0.17	1.8
Colon	COLO 205	0.031	0.008	3.8	0.092	0.015	6.0
Melanoma	UACC-257	0.095	0.033	2.9	5.46
CNS	U251	0.031	0.012	2.7	0.13	0.037	3.6
Breast	MDA-MB-231/ATCC	0.35	0.15	2.4	4.08
Renal	A498	0.028	0.012	2.4	0.20	0.055	3.6
CNS	SF-295	0.25	0.11	2.3	10.2
Non-Small Cell Lung	NCI-H322M	0.23	0.10	2.3	9.02
Renal	CAKI-1	1.89	0.88	2.1	20.9
Renal	SN12C	0.34	0.16	2.1	1.50

TGI ratio = TGI(1)/TGI(2)

LC₅0 ratio = LC₅₀(1)/LC₅₀(2)