Figure 4.

T cell–dependent effects on wound healing in wild-type and mutant mice. A: Wound healing in wild-type and mutant mice 24 hours after anti-Thy1.2 mAb treatment. **P < 0.01, mAb-treated wild-type or mutant mice versus untreated wild-type mice. B: Wound healing in wild-type and mutant mice 24 hours after purified T cell transfer. T^WT and T^ICOS stand for T cells of wild-type and ICOS^−/− mice, respectively. T^WT were transferred into ICOS^−/− mice and ICOSL^−/− mice. T^ICOS were transferred into other ICOS^−/− mice. *P < 0.05, **P < 0.01; T^WT into ICOS^−/− mice versus both T^ICOS into ICOS^−/− mice, and T^WT into ICOSL^−/− mice. C: CD4-positve T^WT and CD8-positve T^WT were transferred into ICOS^−/− mice. *P < 0.05, **P < 0.01 versus unmanipulated ICOS^−/− mice. Each line graph shows the mean (+SEM) results obtained from at least five mice of each group.