Table 1.

Comparison of Micro-Dystrophin Expression, Myofiber Regeneration, and Changes in Postexercise Activity in Individual AAV8.MCK.microdystrophin mdx^5cv Mice

Mouse ID	%μDYS protein	%DYS+fibers	%FCN	Ambulation (%)	Rearing (%)	Distance (%)	Rest time (s)
1	69	51	2.6	−85	−89	−84	1275
2	11	17	14.7	−93	−91	−94	2604
3	20	40	2.2	−82	−83	−73	1189
4	27	30	8.8	−66	−77	−64	694
5	30	30	3.1	−78	−79	−80	1471
mdx5cv controls	—	—	51 ± 5	−91 ± 2	−97 ± 1	−90 ± 9	2029 ± 707

Ambulation, rearing events, and distance travelled are expressed as percentage of change in activity after exercise. Rest time shown is postexercise value after subtraction of rest time value before exercise. Reference values for control mdx^5cv mice represent mean ± SD.

%μDYS, percentage of micro-dystrophin protein expression relative to dystrophin in wild-type diaphragm as determined by Western blot analysis (Figure 6C), and values were normalized to actin as a loading control for each lane; % DYS+fibers, percentage of micro-dystrophin positive myofibers per tissue sections; %FCN, percentage of fibers with central nuclei.