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. 2011 Nov;179(5):2382–2396. doi: 10.1016/j.ajpath.2011.08.002

Figure 7.

Figure 7

In mice, transplantation of T-cell dnTGFβRII bone marrow significantly reduces pneumonitis, fibrosis, and TGF-β levels during latent MHV-68 infection. BMT mice who received T-cell dnTGFβRII bone marrow were infected with 5 × 104 pfu MHV-68. A: Lungs were harvested at day 21 after infection for histologic analysis and stained using H&E and Masson's trichrome (magnification ×100; n = 6 mice; data representative of two independent experiments. B: Lung sections were scored in a blinded fashion by a pathologist (S.F.) on the basis of presence and severity of pathologic features. C: TGF-β levels were measured in BAL fluid at day 21 after infection (n = 4 or 5 mice per group; data representative of two independent experiments). D: Levels of nitrite were measured in BAL fluid at day 21 after infection (n = 3 to 5 mice per group). E and F: Expression of collagen 1 or collagen 3 mRNA was measured in lungs collected at day 21 after infection (n = at least 10 mice per group; data representative of three experiments; *P ≤ 0.05, **P ≤ 0.01, ****P ≤ 0.0001).