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. 2011 Nov;179(5):2589–2600. doi: 10.1016/j.ajpath.2011.07.035

Figure 5.

Figure 5

Increased TIMP-2 and Ala+TIMP-2 levels enhance tumor cell apoptosis. A: Apoptosis in A549 xenograft sections was measured by IHC using a TUNEL assay. Representative photographs shown are from 20 high-power fields taken at ×200 magnification. Brown-colored nuclei indicate apoptotic tumor cells. B: Graph shows the average number of apoptotic cells from 20 high-power fields (×400) per group (EV, T2, Ala+T2). Error bars indicate the mean number of apoptotic cells from the measurement of at least five animals per group. ***P < 0.0001, *P = 0.02 as compared with EV control.