Figure 7.

Dysregulation of SLRP expression in the corneal stroma of 952delTDcn transgenic mice. A: Expression of class I SLRPs, decorin and biglycan, was decreased in 952delTDcn transgenic mice compared with wild-type controls. Semiquantitative immunoblot analyses show a fourfold to eightfold decrease in decorin and a threefold to sevenfold decrease in biglycan expression relative to β-actin. B: Class II SLRPs also show altered expression in the 952delTDcn transgenic mice. The expression of lumican and keratocan is decreased >10-fold. Fibromodulin, which is virtually absent in wild-type corneas, showed consistent and significant expression in the mutant corneas.