Table 2.
Animal Characteristics (Monocrotaline Only)
| Parameter | Controls | M 7 | M 8 | M 14 | M 30 |
|---|---|---|---|---|---|
| Pathology | |||||
| Body weight at day 1, g | 346 ± 20 | 382 ± 10 | 314 ± 7 | 310 ± 8 | 253 ± 16 |
| Body weight at sacrifice, g | 373 ± 24 | 379 ± 7 | 323 ± 6 | 318 ± 12 | 340 ± 18 |
| RV weight, g | 0.22 ± 0.03 | 0.21 ± 0.03 | 0.22 ± 0.04 | 0.18 ± 0.01 | 0.24 ± 0.03 |
| Fulton index [RV/(IVS/LV)] | 0.29 ± 0.04 | 0.26 ± 0.04 | 0.27 ± 0.04 | 0.27 ± 0.03 | 0.32 ± 0.03 |
| Liver wet/dry weight ratio | 2.8 ± 0.3 | 3.0 ± 0.2 | 3.2 ± 0.09 | 3.3 ± 0.1 | 3.2 ± 0.2 |
| Pulmonary vascular remodeling | |||||
| Intra-acinar vessels (<50 μm) | |||||
| Wall thickness, μm | 0.1 ± 0.1 | 0.5 ± 0.2 | 0.9 ± 0.3⁎ | 1.5 ± 0.2⁎ | 3.0 ± 0.6⁎ |
| Wall/lumen ratio | 0.003 ± 0.002 | 0.022 ± 0.010 | 0.035 ± 0.01⁎ | 0.05 ± 0.008⁎ | 0.13 ± 0.03⁎ |
| Muscularization | |||||
| Nonmuscularized, % of vessels | 92 ± 6 | 66 ± 6⁎ | 59 ± 17⁎ | 36 ± 6⁎ | 13 ± 6⁎ |
| Partially muscularized, % of vessels | 7 ± 5 | 24 ± 7⁎ | 34 ± 8⁎ | 42 ± 5⁎ | 28 ± 10⁎ |
| Totally muscularized, % of vessels | 0.8 ± 1 | 6.9 ± 3⁎ | 7 ± 2⁎ | 22 ± 3⁎ | 60 ± 9⁎ |
| Neointima, % of vessels | 0.0 ± 0 | 0.5 ± 1.1 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 |
| Preacinar vessels (>50 μm) | |||||
| Wall thickness, μm | 7 ± 2 | 11 ± 2 | 5 ± 1 | 6 ± 2 | 9 ± 2 |
| Wall/lumen ratio | 0.07 ± 0.02 | 0.14 ± 0.03⁎ | 0.07 ± 0.04 | 0.09 ± 0.01 | 0.08 ± 0.02 |
Muscularization per experimental group is presented as the percentage of intra-acinar vessels per degree of muscularization. Data are presented as mean ± SD from 5 to 10 rats per group.
IVS, intraventricular septum; LV, left ventricle; RV, right ventricle.
⁎
P < 0.05 versus controls.