Figure 2.

Histological assessment of bone marrow, liver, and spleen. Prg4^−/− mutant and Prg4^+/+ wild-type mice were administered intermittent PTH(1–34) (50 μg/kg) or vehicle (VEH) (0.9% NaCl) control subcutaneous injections daily for 6 weeks, from age 16 weeks to 22 weeks. Tibia, liver, and spleen were isolated from 22-week-old Prg4^−/− and Prg4^+/+ mice for histological evaluation. Images are representative images of H&E-stained proximal tibia bone marrow sections (n ≥ 10 per group) (A), liver sections (n ≥ 5 per group) (B), and spleen sections (n ≥ 5 per group) (C). Original magnification: ×40 (A and B); ×20 (C).