Figure 2.

Time-dependent impact of protein C (PC) and activated protein C (APC) treatment for leukocyte adhesion in tumor necrosis factor-α (TNF-α)-stimulated cremaster muscle venules. Leukocyte adhesion (per mm² of vessel surface area) of cremaster muscle venules were measured after 3 hours of TNF-α-induced inflammation and at different time points after injecting a single dose of 100 U/kg PC (A) or after starting continuous administration of 24 μg/kg/hour APC (B). Control mice received isotonic human serum albumin (8 mg/mL) 3 hours before observation. All values are presented as mean ± SEM from at least three mice per group. Significant differences (*P < 0.05) to the control are indicated.