Table 2.
LOX-1 ligands as determined by either direct binding assay or competitive assay (*) against established ligands
| LOX-1 ligand | Molecule |
|---|---|
| Lipoproteins | oxidized LDL |
| acetyl LDL | |
| hypochlorite-modified HDL | |
| remnant-like lipoprotein particle | |
| electronegative LDL | |
| carbamylated LDL | |
| Proteins | CRP |
| fibronectin | |
| HSP60, HSP70 | |
| Cells | activated platelets |
| leukocytes/monocyte | |
| aged/apoptotic cell | |
| bacteria | |
| Phospholipids | phosphatidylserine |
| phosphatidylinositol* | |
| phosphatidic acid* | |
| cardiolipin* | |
| phosphatidylglycerol* | |
| Polyanions | heparin* |
| dextran sulfate* | |
| poly-inosinic acid* | |
| Others | AGE |
| 2-nonenal/4-oxo-nonenal-bound protein |