SEM analysis was performed on brain matrix gels (a, b), native brain tissue (c, d), or Matrigel gels (e, f). SEM reveals that brain matrix gels formed after subcutaneous injection in vivo are composed of a network of nanofibers and microfibers. Matrigel gels are also composed of a meshwork of fibers. Scale bars 5 μm (a, c, e) and 2 μm (b, d, f). SEM, scanning electron microscopy.