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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Nat Neurosci. 2011 Oct 9;14(11):1430–1438. doi: 10.1038/nn.2942

Figure 3. mGluR-induced AMPAR plasticity is developmentally regulated in native OPCs.

Figure 3

(a) Global averaged normalised whole-cell I-V plots for OPCs (6 DIV; n = 14 and 10) traces show means and shaded areas denote S.E.M. Note the increase in rectification following DHPG treatment. Inset shows an immature OPC labelled with antibody against O4 (permeabilized). Scale bar 25 μm. (b) Same as a, for a pre-myelinating OPC developed from OPCs starved of growth factors. I-Vs from 5 cells each. Note the linear I-V in control, and the lack of change following DHPG treatment. (c) Pooled data showing the effect of DHPG treatment on RI in immature OPCs, and the lack of effect in pre-myelinating OPCs.