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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Nat Neurosci. 2011 Oct 9;14(11):1430–1438. doi: 10.1038/nn.2942

Figure 6. TARPs control mGluR-induced AMPAR plasticity.

Figure 6

(a) Global averages of normalized I-V plots obtained from OPCs transfected either with full-length γ-2 (n = 6) or γ-2ΔC308 (n = 7). Filled areas indicate S.E.M. (b) DHPG did not alter AMPAR rectification in OPCs transfected with γ-2ΔC308 (n = 5). (c) Pooled data showing RI values. (d) Averaged glutamate-evoked response (10 mM, 100 ms, −60 mV) recorded in a patch excised from an OPC transfected with GFP alone (mean of 60 responses). Inset shows current-variance plot for this patch. (e) Same as d, for an OPC transfected with γ-2ΔC308 (mean of 68 responses). (f) Pooled normalized data showing the effect of γ-2ΔC308 expression on the weighted mean single-channel conductance (Cond.), Po, peak and τdes.