Table 4.
Analysis of CJD patient s that were not detected in 14-3-3γ protein of WB methods but were beyond the cut-off level (1, 683 AU/ml) in 14-3-3 protein ELISA.
| Age | Sex | type | Polymorphism of codon129 in PRNP gene |
Mutation of PRNP gene |
ELISA of 14-3-3 protein (AU/ml) |
Real-time QUIC |
|---|---|---|---|---|---|---|
| 69 | male | sp | MM | - | 2, 101 | + |
| 33 | female | sp | MM | - | 1, 852 | + |
| 70 | female | sp | MM | - | 2, 452 | - |
| 73 | female | sp | MM | - | 2, 531 | - |
| 64 | male | sp | MM | - | 5, 493 | + |
| 65 | male | fa | MM | E200K | 4, 621 | + |
| 79 | female | sp | VV | - | 2, 342 | + |
sp: sporadic type, ge: genetic type, MM: methioine homozygotes, VV: valine homozygotes, +: positive, -: negative