Table 5.
Analysis of CJD patient s that were not detected in 14-3-3γ protein of WB methods and were below the cut-off level (1, 683 AU/ml) in 14-3-3 protein ELISA.
| Age | Sex | type | Polymorphism of codon129 in PRNP gene |
Mutation of PRNP gene |
ELISA of 14-3-3 protein (AU/ml) |
Real-time QUIC |
|---|---|---|---|---|---|---|
| 85 | female | ge | MM | V180I | 1, 086 | - |
| 84 | female | ge | MM | V180I | 1, 222 | - |
| 84 | male | ge | MM | V180I | 1, 313 | - |
| 84 | female | ge | MM | V180I | 1, 383 | - |
| 75 | male | ge | MM | M232R | 1, 676 | + |
| 78 | male | sp | MM | - | 135 | - |
| 66 | male | sp | MM | - | 1, 224 | + |
sp: sporadic type, ge: genetic type, MM: methioine homozygotes, VV: valine homozygotes, +: positive, -: negative