Table 3.

Current drug use in AD participants compared to controls

	AD n = 187	Control n = 200	Difference*	95%CI*	p-value*
Mean number of drugs ± SD
	5.1 ± 3.6	2.9 ± 2.4	1.48	0.78 to 2.21	< 0.001
Mean number of antihypertensive drugs ± SD
	1.4 ± 1.3	0.8 ± 0.9	0.28	0.012 to 0.538	0.040
Participants using five drugs or more
n(%)	90(48)	46(23)	0.19	0.076 to 0.289	0.001
antihypertensive drugs
n(%)	128(68)	101(50)	0.039	-0.074 to 0.153	0.50
anticholinergic drugs
n(%)	43(23)	12(6)	0.161	0.080 to 0.243	< 0.001
antidepressants
n(%)	24(13)	4(2)	0.091	0.030 to 0.151	0.004
anxiolytic-hypnotic drugs
n(%)	42 (22)	15(8)	0.090	0.008 to 0.172	0.032
inappropriate drugs**
n(%)	69(37)	22(11)	0.193	0.097 to 0.288	< 0.001
lipid lowering agents
n(%)	53(28)	69(35)	0.000	-0.111 to 0.112	0.99

SD = Standard deviation. CI = Confidence interval for age and gender adjusted differences. * Age and gender adjusted. Percentage differences in CIs are expressed in fractions. **According to STOPP criteria for inappropriate drug treatment