Table 3.
Odds ratios for metabolic or glycemic abnormality associated with elevated biomarkers of inflammation and endothelial dysfunction
| No Prediabetes, Diabetes, or MetS |
Prediabetes or Diabetes only |
MetS without Prediabetes or Diabetes |
MetS plus Prediabetes or Diabetes |
|
|---|---|---|---|---|
| hsCRP (mg/L) | ||||
| Age, gender | 1.00 | 2.27 (1.69, 3.06) | 3.00 (2.35, 3.84) | 5.84 (4.53, 7.53) |
| Multivariable | 1.00 | 2.22 (1.65, 3.00) | 2.97 (2.33, 3.80) | 5.70 (4.41, 7.33) |
| Multivariable + BMI | 1.00 | 2.29 (1.69, 3.10) | 2.38 (1.82, 3.11) | 4.82 (3.69, 6.31) |
| sICAM-1 (ng/ml) | ||||
| Age, gender | 1.00 | 2.14 (1.60, 2.86) | 1.13 (0.88, 1.46) | 4.15 (3.24, 5.31) |
| Multivariable | 1.00 | 2.06 (1.54, 2.76) | 1.10 (0.85, 1.43) | 3.98 (3.10, 5.12) |
| Multivariable + BMI | 1.00 | 2.11 (1.58, 2.83) | 0.91 (0.69, 1.21) | 3.43 (2.64, 4.47) |
| sE-selectin (ng/mL) | ||||
| Age, gender | 1.00 | 0.82 (0.60, 1.12) | 1.71 (1.35, 2.17) | 1.27 (0.99, 1.62) |
| Multivariable | 1.00 | 0.82 (0.60, 1.13) | 1.71 (1.35, 2.17) | 1.28 (1.00, 1.64) |
| Multivariable + BMI | 1.00 | 0.85 (0.62, 1.17) | 1.38 (1.06, 1.79) | 1.06 (0.81, 1.38) |
| Angiotensin II (pg/mL) | ||||
| Age, gender | 1.00 | 0.63 (0.45, 0.87) | 1.09 (0.85, 1.39) | 1.05 (0.82, 1.35) |
| Multivariable | 1.00 | 0.63 (0.45, 0.87) | 1.06 (0.83, 1.36) | 1.00 (0.78, 1.29) |
| Multivariable + BMI | 1.00 | 0.62 (0.45, 0.86) | 1.12 (0.86, 1.46) | 1.05 (0.80, 1.37) |
Abbreviations: MetS, Metabolic Syndrome; hsCRP, high sensitivity C-reactive protein; sICAM-1, soluble Intercellular adhesion molecule-1; sE-selectin, soluble E-selectin; BG, blood glucose. The multivariable models are adjusted for age, gender, smoking, drinking and family history of hypertension.