Table 1.
Allelic and genotypic frequencies for the SLCO1B1 polymorphisms according to ethnic groups
| Nucleotide Change and Genotype | African descent | Mulatto | Caucasian descent | Amerindian | p value |
|---|---|---|---|---|---|
| n (100%) | 97 | 332 | 603 | 182 | |
| SLCO1B1 rs4149056 | |||||
| TT | 86 (88.7%) | 241 (72.6%) | 449 (74.5%) | 97 (53.3%) | < 0.001 |
| TC | 11 (11.3%) | 83 (25.0%) | 129 (21.4%) | 67 (36.8%) | |
| CC | 0 | 8 (2.4%) | 25 (4.1%) | 18 (9.9%) | |
| C allele | 5.7% | 14.9% | 14.8% | 28.3% | < 0.001 |
| SLCO1B1 rs4363657 | |||||
| TT | 76 (78.4%) | 216 (65.1%) | 433 (71.8%) | 99 (54.4%) | < 0.001 |
| TC | 21 (21.6%) | 111 (33.4%) | 154 (25.5%) | 71 (39.0%) | |
| CC | 0 | 5 (1.5%) | 16 (2.7%) | 12 (6.6%) | |
| C allele | 10.8% | 18.2% | 15.4% | 26.1% | < 0.001 |
SLCO1B1 rs4149056: c.T521C, p.V174A (exon 5); SLCO1B1 rs4363657: g.T89595C (intron 11).
Mulatto group was composed of mixed ethnicity subjects.
p values were calculated using Chi-square test.