Table 2.
Factors associated with the use of D4T in the first ART regimen in multivariable analysis using log-link Poisson model with robust standard errors.
| Factor | Number (%) (n = 48, 658) |
Risk ratio | 95% Confidence interval | P value |
|---|---|---|---|---|
| Male sex* | 17, 173 | 0.97 | 0.95-0.99 | < 0.001 |
| Year of ART initiation (per 2 years) | 0.81 | 0.73-0.89 | < 0.001 | |
| Country of residence | ||||
| Kenya | 33, 680 | ref | ||
| Uganda | 10, 859 | 0.49 | 0.33-0.72 | < 0.001 |
| Tanzania | 4119 | 1.14 | 1.09-1.21 | < 0.001 |
| Age at ART initiation (years) | ||||
| Quartile 1 (18-31) | 13, 152 | ref | ||
| Quartile 2 (32-37) | 12, 766 | 1.00 | 0.99-1.02 | 0.58 |
| Quartile 3 (38-43) | 10, 662 | 1.00 | 0.99-1.03 | 0.52 |
| Quartile 4 (44-88) | 12, 078 | 0.99 | 0.97-1.02 | 0.56 |
| WHO stage+ | ||||
| Stage 1 | 7263 | ref | ||
| Stage 2 | 9808 | 1.01 | 0.98-1.05 | 0.52 |
| Stage 3 | 21, 291 | 1.06 | 1.02-1.11 | < 0.01 |
| Stage 4 | 7648 | 1.10 | 1.02-1.07 | 0.01 |
| Pre-therapy CD4 level ± | ||||
| ≤ 50 cells/mm3 | 10, 148 | ref | ||
| 51-100 cells/mm3 | 7377 | 0.97 | 0.89-1.06 | 0.27 |
| 101-200 cells/mm3 | 14, 528 | 0.87 | 0.81-0.94 | 0.09 |
| > 200 cells/mm3 | 16, 605 | 0.86 | 0.80-0.93 | 0.02 |
| Presence of tuberculosis | 0.94 | 0.90-0.98 | < 0.01 | |
Each factor is adjusted for all other factors in the table.
* Missing in 106 (0.2%)
+ Missing in 2648 (5.4%)
± Missing in 7283 (15.0%)