Figure 3. The three dimensional crystal structure of the retinol-RBP-TTR complex.
Human retinol-RBP-TTR [29] (PDB ID 1QAB) was generated using Pymol (http://www.pymol.org/). The TTR tetramer (magenta) is comprised of a dimer of dimers with two RBP molecules (red) bound to the opposite dimers. Interactions between RBP and TTR are mediated by residues at the entrance to the ligand binding pocket and span across the two TTR dimers.