. Author manuscript; available in PMC: 2012 Dec 1.

Published in final edited form as: Alcohol Clin Exp Res. 2011 Jul 25;35(12):2174–2183. doi: 10.1111/j.1530-0277.2011.01566.x

Table 4.

Mediation of the effect of prenatal alcohol exposure on trace conditioning by DTI and volumetric measures

	Alcohol during pregnancy
Mediator	β ₁	β ₂	t^a
FA LMP	-0.61^**	-0.28	-2.38^*
λ_⊥ LMP	-0.61^**	-0.39	-1.05
Volume
Total brain	-0.60^*	-0.56^*	-0.64
Cerebellum	-0.60^*	-0.49^†	-1.13
Cerebellar WM	-0.60^*	-0.43^*	-2.22^*
Cerebellar GM	-0.60^*	-0.55^*	-0.54

β₁ = standardized regression coefficient for alcohol during pregnancy before controlling for mediator. β₂ = standardized coefficient for alcohol during pregnancy after controlling for mediator.

FA = fractional anisotropy. LMP = left middle peduncle. λ_⊥ = perpendicular diffusivity. WM = white matter. GM = gray matter.

Significance based on the difference in coefficients method (Clogg et al., 1992). For the DTI measures, df = 15, for the volumetric measures, df = 14.

^†

p < 0.10.

p < 0.05.

^**

p < 0.01.