Skip to main content
. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Addict Biol. 2011 Jul 25;17(3):557–564. doi: 10.1111/j.1369-1600.2011.00345.x

Figure 1.

Figure 1

Effects of LY379268 on reinstatement induced by footshock stress. A: Active lever responses during cocaine self-administration (SA) and extinction (EXT) and the effect of LY379268 on stress-induced reinstatement. Following EXT, exposure to footshock stress produced robust reinstatement of cocaine seeking (0 mg/kg), and LY379268 reversed stress-induced reinstatement at 1 and 3 mg/kg. p < 0.05, compared with extinction (paired t-test; see Results for details); *p < 0.05, compared with 0 mg/kg. Number of animals/group: 0 mg/kg, n = 7; 0.3 mg/kg, n = 7; 1 mg/kg, n = 8; 3 mg/kg, n = 7 B: Cumulative number of responses (per 10 min intervals) throughout the 2 h reinstatement period (error bars omitted for clarity). *p < 0.05, vehicle vs. 1 and 3 mg/kg (Simple Effects analysis; see Results for details).