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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Addict Biol. 2011 Jul 25;17(3):557–564. doi: 10.1111/j.1369-1600.2011.00345.x

Figure 2.

Figure 2

Effects of MTEP on reinstatement induced by footshock stress. A: Active lever responses during cocaine self-administration (SA) and extinction (EXT) and the effect of MTEP on stress-induced reinstatement. As in Fig. 1, footshock stress produced robust reinstatement of cocaine seeking under MTEP vehicle conditions (0 mg/kg). MTEP prevented stress-induced reinstatement at 0.3, 1, and 3 mg/kg. †p < 0.05, compared with extinction (paired t-test; see Results for details), *p < 0.05, compared with 0 mg/kg Number of animals/group: 0 mg/kg, n = 7; 0.3 mg/kg, n = 7; 1 mg/kg, n = 7; 3 mg/kg, n = 8. B: Cumulative number of responses (per 10 min intervals) throughout the 2 h reinstatement period (error bars omitted for clarity). *p < 0.05, vehicle vs. 0.3, 1, and 3 mg/kg (Simple Effects analysis; see Results for details).