Table III.

Associations between candidate SNPs and colon and rectal cancer

	Controls	Cases		Wald
	N	N	ORa (95% CI)	P value	pACT
Colon
IFNG (rs1861493)				0.0007	0.0019
AA	947	849	1.00
AG/GG	1008	704	0.79 (0.69–0.91)
IRF2 rs3775554 (G > C)				0.0205	0.5099
GG	1479	1218	1.00
GC	443	322	0.88 (0.74–1.03)
CC	34	15	0.52 (0.28–0.97)
IRF2 (rs793801)				0.0112	0.3392
GG	666	590	1.00
GA/AA	1290	964	0.84 (0.73–0.96)
IRF2 (rs809909)				0.0097	0.3093
TT	878	626	1.00
TA/AA	1078	929	1.20 (1.04–1.37)
IRF3 (rs2304204)				0.0041	0.0080
AA/AG	1817	1397	1.00
GG	139	157	1.43 (1.12–1.82)
Summary score
(0–2)	305	172	1.00
(3–5)	911	653	1.27 (1.02–1.57)
(6–7)	555	524	1.66 (1.33–2.08)
(8–10)	185	206	1.92 (1.46–2.53)
Ptrend	<0.0001
Rectal
IFNGR1 (rs3799488)				0.0400	0.1120
TT/TC	949	737	1.00
CC	10	17	2.30 (1.04–5.09)
IFNGR2 (rs2834211)				0.0222	0.0949
TT	764	565	1.00
TC/CC	195	189	1.31 (1.04–1.64)
IRF2 (rs3733473)				0.0173	0.4518
GG	625	449	1.00
GA/AA	334	305	1.27 (1.04–1.55)
IRF2 (rs3775556)				0.0071	0.2338
AA	532	369	1
AG	370	328	1.26 (1.03–1.54)
GG	55	57	1.48 (0.99–2.19)
IRF2 (rs3775574)				0.0029	0.1119
AA	317	297	1.00
AG/GG	642	457	0.74 (0.60–0.90)
IRF4 (rs11242865)				0.0184	0.1458
CC/CT	935	720	1.00
TT	24	34	1.90 (1.11–3.24)
IRF6 (rs861020)				0.0313	0.1296
GG/GA	910	732	1.00
AA	49	22	0.57 (0.34–0.95)
IRF8 (rs1044873)				0.0142	0.1317
CC/CT	789	654	1.00
TT	170	100	0.71 (0.55–0.93)
Summary score
(0–4)	251	122	1.00
(5–6)	390	280	1.47 (1.13–1.92)
(7–8)	229	232	2.10 (1.58–2.79)
(9–12)	89	120	2.79 (1.96–3.96)

^aOR and 95% CI adjusted for age, center, race/ethnicity and sex.