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. 2011 Aug 22;32(11):1689–1696. doi: 10.1093/carcin/bgr191

Fig. 2.

Fig. 2.

Histopathological and histochemical analysis of mPanIN lesions in KrasG12D/Pdx1-Cre mice. (A–C) Representative photos of mPanIN-1, mPanIN-2 and mPanIN-3, respectively. (D) Semiquantitative analysis (histogram) of mPanIN lesions. Statistically significant lower in the incidence of high-grade mPanIN-2 and mPanIN-3 lesions were observed in mice fed capsaicin-supplemented diets compared with AIN-76A diet alone (Chi-square test, P < 0.05). Alcian blue/PAS staining of mucin in mPanIN lesions in (E) mice fed AIN-76A diet alone, or (F and G) mice fed capsaicin-supplemented diets. (H) Statistical analysis of PAS/Alcian blue-positive staining areas in the control and capsaicin treatment groups (Chi-square test, P < 0.05).