Table II.
Genotype frequencies of the TNFAIP2 polymorphisms among SCCHN cases and control subjects and their associations with SCCHN risk in a case–control study conducted at M. D. Anderson Cancer Center in Houston, TX between October 1999 and October 2007
| Genotypes | Controls (%) | Overall |
Oropharynx |
Non-oropharynxa |
|||
| Cases (%) | OR (95% CI)b | Cases (%) | OR (95% CI)b | Cases (%) | OR (95% CI)b | ||
| All subjects | 1073 (100.0) | 1077 (100.0) | 549 (100.0) | 528 (100.0) | |||
| rs8126 T > C | |||||||
| TT | 548 (51.1) | 488 (45.3) | 1.00 | 249 (45.4) | 1.00 | 239 (45.3) | 1.00 |
| CT | 441 (41.1) | 483 (44.9) | 1.18 (0.98–1.43) | 242 (44.1) | 1.18 (0.94–1.47) | 241 (45.6) | 1.22 (0.96–1.55) |
| CC | 84 (7.8) | 106 (9.8) | 1.48 (1.06–2.05) | 58 (10.5) | 1.53 (1.04–2.23) | 48 (9.1) | 1.32 (0.86–2.03) |
| Ptrend | 0.009 | 0.022 | 0.075 | ||||
| CC/CT | 525 (48.9) | 589 (54.7) | 1.23 (1.03–1.47) | 300 (54.6) | 1.24 (1.01–1.54) | 289 (54.7) | 1.24 (0.98–1.56) |
| rs710100 G > A | |||||||
| GG | 515 (48.0) | 492 (45.7) | 1.00 | 254 (46.3) | 1.00 | 238 (45.1) | 1.00 |
| AG | 459 (42.8) | 474 (44.0) | 1.05 (0.87–1.27) | 234 (42.6) | 1.02 (0.81–1.28) | 240 (45.5) | 1.12 (0.88–1.42) |
| AA | 99 (9.2) | 111 (10.3) | 1.22 (0.89–1.67) | 61 (11.1) | 1.29 (0.90–1.86) | 50 (9.5) | 1.12 (0.74–1.69) |
| Ptrend | 0.242 | 0.279 | 0.396 | ||||
| AA/AG | 558 (52.0) | 585 (54.3) | 1.08 (0.90–1.29) | 295 (53.7) | 1.07 (0.86–1.32) | 290 (54.9) | 1.12 (0.89–1.41) |
| rs1052912 G > A | |||||||
| GG | 858 (80.0) | 831 (77.2) | 1.00 | 423 (77.1) | 1.00 | 408 (77.3) | 1.00 |
| AG | 213 (19.8) | 238 (22.1) | 1.13 (0.91–1.41) | 123 (22.4) | 1.14 (0.88–1.48) | 115 (21.7) | 1.13 (0.85–1.49) |
| AA | 2 (0.2) | 8 (0.7) | 4.35 (0.87–21.81) | 3 (0.5) | 3.10 (0.50–19.43) | 5 (1.0) | 4.82 (0.69–33.84) |
| Ptrend | 0.108 | 0.203 | 0.212 | ||||
| AA/AG | 215 (20.0) | 246 (22.8) | 1.16 (0.94–1.44) | 126 (22.9) | 1.16 (0.90–1.50) | 120 (22.7) | 1.16 (0.88–1.1.53) |
| rs1052823 G > T | |||||||
| GG | 852 (79.4) | 830 (77.1) | 1.00 | 422 (76.9) | 1.00 | 408 (77.3) | 1.00 |
| GT | 205 (19.1) | 228 (21.2) | 1.12 (0.89–1.39) | 115 (20.9) | 1.09 (0.84–1.43) | 113 (21.4) | 1.13 (0.85–1.50) |
| TT | 16 (1.5) | 19 (1.7) | 1.35 (0.66–2.73) | 12 (2.2) | 1.65 (0.75–3.66) | 7 (1.3) | 0.98 (0.37–2.64) |
| Ptrend | 0.227 | 0.243 | 0.479 | ||||
| TT/GT | 221 (20.6) | 247 (22.9) | 1.13 (0.91–1.40) | 127 (23.1) | 1.13 (0.87–1.46) | 120 (22.7) | 1.12 (0.85–1.48) |
a
Included oral cavity (n = 315), larynx (n = 170) and hypopharyngeal (n = 43).
b
Adjusted for age, sex, pack-years and alcohol consumption in a logistic regression model.