Table III.
SCCHN risk associated with TNFAIP2 rs8126 genotypes by selected subject characteristics in a case–control study conducted at M. D. Anderson Cancer Center in Houston, TX between October 1999 and October 2007
| Variables | Cases (n = 1077) |
Controls (n = 1073) |
Adjusted OR (95% CI)a |
Pa | |||
| TT | CC/CT | TT | CC/CT | TT | CC/CT | ||
| n (%) | n (%) | n (%) | n (%) | ||||
| Age (years) | |||||||
| ≤57 | 268 (46.5) | 308 (53.5) | 280 (50.0) | 280 (50.0) | 1.00 | 1.10 (0.86–1.40) | 0.445 |
| >57 | 220 (43.9) | 281 (56.1) | 268 (52.2) | 245 (47.8) | 1.00 | 1.40 (1.08–1.82) | 0.012 |
| Sex | |||||||
| Female | 134 (50.2) | 133 (49.8) | 147 (58.6) | 104 (41.4) | 1.00 | 1.26 (0.86–1.83) | 0.232 |
| Male | 354 (43.7) | 456 (56.3) | 401 (48.8) | 421 (51.2) | 1.00 | 1.21 (0.99–1.48) | 0.067 |
| Pack-years | |||||||
| None | 144 (47.7) | 158 (52.3) | 284 (54.3) | 239 (45.7) | 1.00 | 1.30 (0.98–1.74) | 0.071 |
| ≤21.0 | 113 (48.1) | 122 (51.9) | 133 (47.2) | 149 (52.8) | 1.00 | 1.03 (0.72–1.47) | 0.880 |
| >21.0 | 231 (42.8) | 309 (57.2) | 131 (48.9) | 137 (51.1) | 1.00 | 1.30 (0.96–1.76) | 0.091 |
| Alcohol consumption (average drinks per week) | |||||||
| None | 144 (49.2) | 149 (50.8) | 221 (47.7) | 242 (52.3) | 1.00 | 0.94 (0.70–1.27) | 0.700 |
| ≤8.0 | 118 (42.8) | 158 (57.2) | 185 (56.9) | 140 (43.1) | 1.00 | 1.76 (1.26–2.45) | 0.001 |
| >8.0 | 226 (44.5) | 282 (55.5) | 142 (49.8) | 143 (50.2) | 1.00 | 1.19 (0.88–1.61) | 0.262 |
a
Adjusted for age, sex, pack-years and alcohol consumption in a logistic regression model, where it was appropriate.