Figure 5.
Localizing regulatory activity in the CD4 T cell subset. (A, B) RVSP and RVH measurements in athymic rats after SU5416 administration and IR with fractionated CD8+ T cells (n=7-14/group). (C,D) RVSP and RVH measurements in athymic rats after SU5416 administration undergoing IR with CD4-depleted spleen cells (n=8-11/group). (E,F) RVSP and RVH measurements in euthymic rats after SU5416 administration and undergoing CD4 depletion (n=8-13/group). (G,H) RVSP and RVH measurements in athymic rats after SU5416 administration and undergoing reconstitution with CD4+CD25hi cells and CD4+CD25- cells (n=14-16/group). Data are shown as means with error bars representing SEM. * p<0.05.