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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Mol Microbiol. 2011 Jul 19;81(4):1020–1033. doi: 10.1111/j.1365-2958.2011.07748.x

Fig. 1. Working model for the regulation of membrane phospholipid biosynthesis in V. cholerae.

Fig. 1

A. Phosphatidic acid biosynthesis from exogenous acyl chains in V. cholerae. Phosphatidic acid synthesis is initiated by the PlsB-catalyzed transfer of fatty acyl chains to G3P from acyl-CoA, and subsequent PlsC-catalyzed acylation of acyl-G3P. LCFA: Long chain fatty acids; G3P: sn-glycerol-3-phosphate; LPA: 1-acylG3P; PA: phosphatidic acid.

B. Cartoon of the model for regulation of plsB expression in V. cholerae (the fad regulon would be similarly regulated). Binding of acyl-CoA results in dramatic rearrangement of the FadR C-terminal domain which drives the N-terminal DNA binding domains into a conformation which precludes cooperative DNA binding (van Aalten et al., 2001).