Table 2.
Centrosome amplification in human haematological cancers and pre-neoplasia
| Cancer type | n | CA (%) | CIN | Association | Ref | |
|---|---|---|---|---|---|---|
| Samples | Intratumoural | |||||
| cHL | 2 | 100 | - | - | ˟Aurora-A, PLK1 | 177 |
| cHL | 31 | 90 | - | - | - | 178 |
|
Total NHL DLBCL MCL - Tetraploid - Diploid FL - High grade - Low grade MZBCL |
92 18 12 19 8 16 17 |
100 100 100 100 100 100 100 |
32 42 56 31 30 23 29 |
- - Y - - |
˟p53 | 175 |
| MCL - Tetraploid - Diploid |
9 24 |
100 100 |
56 36 |
Y | - | 179 |
| BL | 1 | 100 | 30-50 | N | - | 182 |
| B-CLL | 64 | 100 | 18 | N | - | 180 |
| B-CLL MBL |
70 4 |
100 100 |
26 12 |
N | - | 176 |
| ALCL | 17 | 41 | - | - | ˟p53 | 181 |
| CML - CP - BC |
18 16 |
100 100 |
29 54 |
Y | - | 183 |
| CML - CP - BC |
5 5 |
100 |
35 59 |
- | - | 184 |
| CML (CP) SM |
29 2 |
100 100 |
13-26 16 |
- | - | 188 |
| AML | 51 | 100 | 36 | Y | - | 190 |
| Marrow failure - AA - MDS - PNH |
15 9 1 |
27 11 0 |
10-24 | Y | - | 192 |
| ATL | 8 | 88 | 19 | - | - | 194 |
| MM (Plasma cells) MGUS |
41 8 |
100 - |
26 14 |
- | RHAMM expression | 197 |
| MM (Plasma cells) SMM MGUS |
14 7 3 |
64 71 67 |
26 20 12 |
N | - | 12 |
| MM - Plasma cells - B cells |
50 38 |
17 37 |
9 10 |
- | - | 198 |
| GIST | 1 | 100 | 17 | - | - | 188 |
n, sample size; CA, centrosome amplification; CIN, chromosomal instability/aneuploidy; cHL, classic Hodgkin's lymphoma; NHL, non-Hodgkin's lymphoma; DLBCL, diffuse large B-cell lymphoma; MCL, mantle cell lymphoma; FL, follicular lymphoma; MZBCL, marginal zone B-cell lymphoma; BL, Burkitt's lymphoma; B-CLL, B-cell chronic lymphocytic leukaemia; MBL, monoclonal B-cell lymphocytosis; ALCL, ALK-positive anaplastic large cell lymphoma; ATL, adult T-cell leukaemia; AML, acute myeloid leukaemia; CML, chronic myeloid leukaemia; CP, chronic phase; BC, blast crisis; SM, systemic mastocytosis; AA, aplastic anemia; MDS, myelodysplastic syndrome; PNH, paroxysmal nocturnal hemoglobinuria; MM, multiple myeloma; SMM, smouldering multiple myeloma; MGUS, monoclonal gammopathy of undetermined significance; ˟, no association; Y, positive association; N, no association