Figure 2.

A–H, Exposure to GCV eliminates greater number of neurons during the juvenile period (A–D) compared with adulthood (E–H). A, E, Schematic timelines for the juvenile-ablation (A) and adult-ablation (E) cohorts. B, C, F, G, Exposure to GCV during the juvenile period eliminated significantly more BrdU-positive cells in the MOB (B, F) and DG (C, G) compared with adulthood. D, H, Exposure to GCV in the juvenile period and adulthood eliminated similar numbers of non-neuronal BrdU-positive cells in the corpus callosum. Same y-axis scales were used for each brain region to emphasize scope of NSC elimination in these two age groups. Error bars represent mean ± SEM. *p < 0.05, ***p < 0.001, unpaired Student's t test. ICV, Intracerebroventricular.