Figure 3.

A–J, Ablating juvenile (A–E) and adult (F–J) neurogenesis causes similar behavioral outcomes in tests of anxiety and memory. Ablation of neurogenesis, in both ages, had no effect on time spent in the center (A, F) or distance traveled (B, G) in the open field, but increased time in the illuminated area (C, H) and number of transitions (D, I) in the dark–light test and impaired performance in the object-recognition task (E, J). PI in E and J was calculated as a percentage of the time the mouse explored the novel object divided by the total time spent exploring both objects. Error bars represent mean ± SE. *p < 0.05, **p < 0.01, unpaired Student's t test.