Fig. (1).

Tat-tg mice infected with M. tuberculosis W-Beijing SA161 show decreased survival compared to non-tg mice, but similar lung bacterial burden. (a) Survival of non-tg and Tat-tg mice was monitored after a low dose aerosol infection with M. tuberculosis W-Beijing SA161 (blue closed circles and red open squares, respectively) or the control laboratory strain H37Rv (orange hash marks and grey open circles, respectively). n=5 mice per group. The arrows indicate day 65 post infection. (b) Bacterial counts from non-tg (blue bars) and Tat-tg mice (red bars) infected with W-Beijing SA161 at the indicated times post infection. Results are expressed as the average Log₁₀ CFUe (±SE) of the bacterial load in each experimental group (n=4).