Table I.

Components of the Death Inducing Signaling Complex for Fas, TRAIL and TNF. *Membrane Bound Complex. Main Evidences from native Immunoprecipitation Experiments or from Yeast Two-hybrid and Co-immunoprecipitation Assays.

	TNF-R1	TRAIL-R1, TRAIL-R2	Fas
Apoptosis	Complex II	Complex I*	Complex I*
	(in absence of TNF-R1)	FADD [80,81]	FADD [82,87,111]
	RIP [83,85,89]	Caspase-8 [80,92]	Caspase-8 [86]
	TRADD [83,85,89]	Caspase-10 [88,93,96]	Caspase-10 [88,90,93,95]
	FADD [83,85,89]	c-FLIP [84,94,97]	c-FLIP [84,91,94]
	Caspase-8 [83,85,89]
	Caspase-10 [89]
	c-FLIP [89]
Non-apoptotic signalling	Complex I *	Complex II	Complex II
	TRADD [102-104]	RIP-1 [85,110]	(in absence of CD95)
	TRAF-2 [102,104]	TRAF2 [110]	FADD [105]
	RIP1 [102]	Caspase-8 [110]	Caspase-8 [105]
	IKKγ [98]	FADD [110]	cFLIP [105]
	IKKα, IKKβ [98,99]	IKKγ [85,110]	RIP1 [100]
	cIAP1 [106-108]	TRADD [85]
	cIAP2 [106,107]
	LUBAC ligase complex [101,109]