Table I.
TNF-R1 | TRAIL-R1, TRAIL-R2 | Fas | |
---|---|---|---|
Apoptosis | Complex II | Complex I* | Complex I* |
(in absence of TNF-R1) | FADD [80,81] | FADD [82,87,111] | |
RIP [83,85,89] | Caspase-8 [80,92] | Caspase-8 [86] | |
TRADD [83,85,89] | Caspase-10 [88,93,96] | Caspase-10 [88,90,93,95] | |
FADD [83,85,89] | c-FLIP [84,94,97] | c-FLIP [84,91,94] | |
Caspase-8 [83,85,89] | |||
Caspase-10 [89] | |||
c-FLIP [89] | |||
Non-apoptotic signalling | Complex I * | Complex II | Complex II |
TRADD [102-104] | RIP-1 [85,110] | (in absence of CD95) | |
TRAF-2 [102,104] | TRAF2 [110] | FADD [105] | |
RIP1 [102] | Caspase-8 [110] | Caspase-8 [105] | |
IKKγ [98] | FADD [110] | cFLIP [105] | |
IKKα, IKKβ [98,99] | IKKγ [85,110] | RIP1 [100] | |
cIAP1 [106-108] | TRADD [85] | ||
cIAP2 [106,107] | |||
LUBAC ligase complex [101,109] |