Group, age, y
|
Prevaccination GMT (95% CI)
|
Prevaccination seroprotection rate, %
|
Postvaccination GMT (95% CI)
|
Postvaccination seroprotection rate, %
|
p value
|
Children <5, n = 40) |
|
|
|
|
|
HI
|
10.4 (9.9–10.9)
|
0
|
ND
|
ND
|
ND
|
Adults 20–49, n = 36 |
|
|
|
|
|
HI |
12.1 (10.7–13.7) |
2.8 |
12.1 (10.7–13.7) |
2.80 |
NS |
MN
|
26.3 (20.9–32.8)
|
0
|
31.7 (25.0–40.3)
|
0
|
<0.05
|
Older adults 50–74, n = 50 |
|
|
|
|
|
HI |
16.7 (14.2–19.7) |
16 |
16.7 (14.2–19.7) |
16 |
NS |
MN
|
59.0 (47.7–72.8)
|
20
|
74.6 (60.0–92.9)
|
32
|
<0.05
|
Elderly adults >75, n = 50 |
|
|
|
|
|
HI |
22.7 (19.5–26.4) |
36 |
23.3 (19.8–27.4) |
38 |
0.159 |
MN
|
85.7 (70.8–103.9)
|
32
|
107 (89.2–128.5)
|
44
|
<0.05
|
*GMT, geometric mean titer; CI, confidence interval; HI, hemagglutination inhibition; ND, not done; NS, not significant. MN, microneutralization. Mean ± SD ages for the 4 groups were 20.0 ± 11.3 mo for children, 34.5 ± 7.5 y for adults, 65 ± 6 y for older adults, and 79 ± 3.3 y for elderly adults. |