Table 5.
Multivariate analysis of overall mortality and nonrelapse mortality
| Overall mortality (54 events) |
Nonrelapse mortality (41 events) |
|||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| NIH severity | ||||
| Mild (n = 32) | 1.0 | 1.0 | ||
| Moderate (n = 175) | 5.0 (0.7-38) | 2.9 (0.4-22) | ||
| Severe (n = 91) | 13.1 (1.8-97) | < .0001 | 10.9 (1.5-81) | < .0001 |
| Platelets, 109/L | ||||
| ≥ 100 | 1.0 | 1.0 | ||
| < 100 | 3.1 (1.7-5.6) | .0006 | 3.4 (1.7-6.7) | .001 |
| KPS at onset | ||||
| 80+ | 1.0 | 1.0 | ||
| ≤ 70 | 2.1 (1.2-3.8) | 2.0 (1.0-4.0) | ||
| Missing | 1.2 (0.5-3.1) | .05 | 1.5 (0.5-4.1) | .13 |
| Donor | ||||
| Matched related | 1.0 | 1.0 | ||
| Matched URD | 0.8 (0.4-1.5) | 0.7 (0.4-1.5) | ||
| Mismatched | 1.0 (0.5-2.0) | .80 | 0.7 (0.3-1.8) | .62 |
| Age at transplantation, y | ||||
| Adult < 50 | 1.0 | 1.0 | ||
| Adult ≥ 50 | 1.2 (0.7-2.1) | .60 | 1.1 (0.6-2.1) | .83 |
| Disease stage | ||||
| Early | 1.0 | 1.0 | ||
| Intermediate | 1.4 (0.7-2.7) | 1.2 (0.6-2.7) | ||
| Advanced | 1.3 (0.6-2.9) | .63 | 1.7 (0.7-4.0) | .50 |
HR indicates hazard ratio; CI, confidence interval; NIH, National Institutes of Health; KPS, Karnofsky performance status; and URD, unrelated donor.